Thursday 26 March 2009

Cumulative Selection

I'm sick of studying but I haven't much to blog about. Solution? Quote Dr. Dawkins!

"It is amazing that you can still read calculations like my haemoglobin calculation, used as though they constituted arguments against Darwin's theory. The people who do this, often expert in the their own field ... seem sincerely to believe that Darwinism explains living organisation in terms of chance - 'single-step selection' - alone. This belief, that Darwinian evolution is 'random', is not merely false. It is the exact opposite of the truth. Chance is a minor ingredient in the Darwinian recipe, but the most important ingredient is cumulative selection which is quintessentially nonrandom."
~ The Blind Watchmaker, Chapter 3, 1986


As I read this book I keep getting the uncanny feeling Dawkins is reading my thoughts. Early on, he mentions that natural selection is not purposeful, just an inevitable occurrence when you have variation within a population that reproduces and passes on its characteristics. I thought to myself that thinking this is in some way directed is like thinking that a sieve in a river catching large but not small objects is doing it for a purpose. This organisation out of chaos is not for anything, it's just a consequence of how sieves work. Two pages later and he's talking about sieves. I guess it's just a common example.

Wednesday 18 March 2009

DNA Extractions

As I've mentioned before, there are certain moments in the string of routines, adjustments, retries and self-corrections that makes up an experiment which are particularly beautiful or elegant. It's generally the moment when it all makes sense, when you end up with a number which proves that the past three hours of pedantic measuring was not in vain.

In our extraction of DNA (from chicken liver in Molecular & Cellular Regulation), that moment didn't come at the end at all. Yes, we've since got those all important numbers from spectrophotometry and electrophoresis, but the awesome part is the fiddliest. The DNA and a bit of other sludge (proteins etc) are in the bottom of the tube, topped with a layer of ethanol (pipetted ever so carefully down the side of the glass so they don't mix). In goes your glass rod, and ever so delicately you dip it past the interface and swirl it around in the DNA to wind a few strands onto the rod. It's like making the world's tiniest stick of fairy-floss. The strands precipitate out when they reach the ethanol, and hang there, translucent, the stuff we're made of.

I don't believe humans have a 'soul', or anything more than the sum of our parts, than the complexities of the brain. I find it hugely more impressive, more inspiring and wonderful to think of the intricacies of how we work, come about over millions of years by a process born out of randomness and determined by the ability to survive, than to propose that we are something more mysterious.

Year #2

With second year comes... more failed resolutions to post often, it seems. I will endeavour.

Meanwhile, my classes all feel a lot more focused. Currently my minor ("co-major") is Life Science Technologies, which translates to 'pick some stuff you're interested in from the life sciences'. However I'm considering changing it to biomolecular science, or even making biochem my minor and changing major to biomolecular. Anyway, I have plenty of time to decide because they have so many units in common. This semester, it's Microbiology, Molecular and Cellular Regulation, Biochemistry and Medical Physiology. As usual I'm not a huge fan of microbiology, but I'm enjoying the others, even (gasp) physiology.

Med Phys is interesting in that we don't have lectures; the material is all online and backed up in the tutes and pracs. I'm quite enjoying this (more time sleeping in the morning!) but I think other subjects wouldn't be so suited to it. We've also got the benefit of a really well-made website, which is vastly better than my experiences with textbook-linked websites made by book publishers. Thankfully none of those are compulsory this time around.